| 发明名称 | <i>Lutzomyia longipalpis </i>polypeptides and methods of use | ||
| 摘要 | Substantially purified salivary Lu. longipalpis polypeptides, and polynucleotides encoding these polypeptides are disclosed. Vectors and host cells including the Lu. longipalpis polynucleotides are also disclosed. In one embodiment, a method is disclosed for inducing an immune response to sand fly saliva. In other embodiments, methods for treating, diagnosing, or preventing Leishmaniasis are disclosed. | ||
| 申请公布号 | US9382302(B2) | 申请公布日期 | 2016.07.05 |
| 申请号 | US201514802168 | 申请日期 | 2015.07.17 |
| 申请人 | The United States of America as represented by the Secretary of the Department of Health and Human Services;Fundação Oswaldo Cruz (FIOCRUZ) | 发明人 | Valenzuela Jesus G.;Ribeiro Jose M. C.;Barral Aldina;Netto Manoel Barral;Brodskyn Claudia I.;Gomes Regis |
| 分类号 | C12N15/63;C07H21/04;C07K14/00;A61K39/00;C07K14/44;A61K39/008;C07K14/435;C07K16/18;C07K16/20;A61K38/00 | 主分类号 | C12N15/63 |
| 代理机构 | Klarquist Sparkman, LLP | 代理人 | Klarquist Sparkman, LLP |
| 主权项 | 1. An expression vector comprising: a nucleic acid sequence encoding a salivary Lu. longipalpis polypeptide, wherein the polypeptide comprises amino acid residues 24-301 of SEQ ID NO: 15; and a heterologous expression control sequence. | ||
| 地址 | Washington DC US | ||