ANTI-INFLAMMATORY AND MYDRIATIC INTRACAMERAL SOLUTIONS FOR INHIBITION OF POSTOPERATIVE OCULAR INFLAMMATORY CONDITIONS

摘要

The present invention provides methods for inhibiting postoperative inflammatory conditions following ophthalmologic surgical procedures by administering intraocularly during an ophthalmologic surgical procedure a solution including a nonsteroidal anti-inflammatory agent and an alpha-1 adrenergic mydriatic agent, such as a liquid irrigation solution of ketorolac and phenylephrine.

主权项

1. A method for inhibiting a postoperative inflammatory condition following an ophthalmologic surgical procedure comprising:
identifying a subject with an elevated risk of suffering from a postoperative inflammatory condition; administering intraocularly to the subject during an ophthalmologic surgical procedure a solution including a nonsteroidal anti-inflammatory drug (NSAID) and an alpha-1 adrenergic receptor agonist mydriatic agent in an intraocular irrigation carrier, wherein the NSAID and the mydriatic agent are included in the solution in amounts sufficient to maintain intraoperative pupil diameter by promoting mydriasis and inhibiting miosis, and a sufficient amount of the solution is administered for uptake of an amount of the NSAID in ocular tissues sufficient for inhibition of cyclooxygenases for a period of at least six hours postoperatively, thereby inhibiting the postoperative inflammatory condition.