Substituted benzoxazoles

摘要

The invention relates to substituted benzoxazoles and to processes for their preparation and to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular of cardiovascular disorders, preferably of thrombotic or thromboembolic disorders.

主权项

1. A compound of the formula in which R1 represents a group of the formula where * is the point of attachment to the carbonyl group,X represents an oxygen atom, a sulphur atom or CH—R6, where
R6 represents hydroxyl,R2 represents hydrogen, C1-C6-alkyl, C3-C6-cycloalkyl or phenyl,
where alkyl and cycloalkyl may be substituted by a substituent selected from the group consisting of hydroxy, methoxy, cyano, hydroxycarbonyl, aminocarbonyl, methylsulphonyl, difluoromethoxy and trifluoromethoxy,orwhere alkyl and cycloalkyl may be substituted by 1 to 3 fluorine substituents,R3 represents hydrogen or C1-C4-alkyl,orR2 and R3 together with the carbon atom to which they are attached form a cyclopropyl ring, cyclobutyl ring or cyclopentyl ring,
where the cyclobutyl ring and the cyclopentyl ring may be substituted by ahydroxyl substituent,R4 represents hydrogen or C1-C6-alkyl,
where alkyl may be substituted by a hydroxyl substituent,R5 represents C1-C4-alkyl,orR4 and R5 together with the carbon atom to which they are attached form a cyclopropyl ring, cyclobutyl ring or cyclopentyl ring,
where the cyclobutyl ring and the cyclopentyl ring may be substituted by ahydroxyl substituent,R7 represents hydrogen or C1-C6-alkyl,
where alkyl may be substituted by a hydroxyl or cyano substituent, orwhere alkyl may be substituted by 1 to 3 fluorine substituents,R8 represents hydrogen,R9 represents hydrogen or C1-C6-alkyl,
where alkyl may be substituted by a hydroxyl or cyano substituent,orwhere alkyl may be substituted by 1 to 3 fluorine substituents,R10 represents hydrogen,R11 represents C1-C4-alkyl,
where alkyl may be substituted by a hydroxyl substituent,R12 represents hydrogen or C1-C4-alkyl,orR11 and R12 together with the carbon atom to which they are attached form a cyclopropyl ring, cyclobutyl ring or cyclopentyl ring,
where the cyclobutyl ring and the cyclopentyl ring may be substituted by a hydroxyl substituent,R13 represents hydroxymethyl or hydroxyethyl,R14 represents methoxy or ethoxy, or one of the salts thereof, solvates thereof or solvates of the salts thereof.