SOLID FORM OF ABIRATERONE ACETATE

摘要

Combinations of (3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate (Abiraterone acetate) with acidic substances such as citric acid, ascorbic acid, methyl-4-hydroxy benzoate, saccharin, vanillic acid, adipic acid, maleic acid, malic acid, tartaric acidare useful as pharmaceutical preparations and show improved properties such as aqueous solubility and dissolution kinetics, especially in the form of cocrystals or their combination with a suitable acid.

主权项

1. A pharmaceutical composition, comprising:
(3β)-17-(pyridin-3-yl)androsta-5,16-dien-3-yl acetate; and at least one pharmaceutically acceptable organic acid, which is solid at standard conditions and has pKa of less than 5.0.