| 摘要 |
PROBLEM TO BE SOLVED: To provide a process for efficiently preparing a substituted amino acid Schiff base compound (3) shown below with industrial advantage which is useful as an intermediate for producing drugs, agricultural chemicals and the like. SOLUTION: The process for preparing the substituted amino acid Schiff base compound (3) (wherein R<SP>1</SP>is a 1-8C alkyl group or the like; R<SP>2</SP>is a 1-8C alkyl group or the like; R<SP>3</SP>is a 1-8C alkyl group or the like; Ar is an aryl group or the like; and R<SP>4</SP>is a 1-8C alkyl group) comprises reacting an amino acid Schiff base compound (1) (wherein R<SP>1</SP>, R<SP>2</SP>, R<SP>3</SP>, and Ar are the same as defined above) with a compound represented by formula (2) (wherein R<SP>4</SP>is the same as defined above and L is an elimination group) in the presence of an alkali metal hydroxide or the like and a crown ether. In this instance, when an optically active quaternary ammonium salt is allowed to be present, an optically active substituted amino acid Schiff base compound (3) can be prepared. COPYRIGHT: (C)2008,JPO&INPIT
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