METHOD OF AND APPARATUS FOR IDENTIFYING PHENOTYPE-SPECIFIC GENE NETWORK USING GENE EXPRESSION DATA

摘要

In a method of identifying a phenotype-specific gene network using gene expression data, gene networks are generated using the gene expression data and biological interaction data, a sub-network commonly existing among generated gene networks is searched for, one or more clusters are extracted from a common sub-network, and a cluster related to a change of a phenotype of a biological sample is determined by verifying significance for each of extracted one or more clusters.

主权项

1. A processor-implemented method of identifying a phenotype-specific gene network using gene expression data, the method comprising the steps, implemented in a processor, of:
receiving gene expression data and biological interaction data; generating two or more gene networks corresponding to two or more time points included in the gene expression data using the gene expression data and the biological interaction data; searching for a common sub-network commonly existing among the two or more generated gene networks; extracting one or more clusters from the common sub-network; and determining a cluster related to a change of a phenotype of a biological sample by verifying a significance of a development of gene expression levels of gene nodes according to a change of the time points for each of the extracted one or more clusters.