Pharmaceutical compositions providing enhanced drug concentrations

摘要

A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.

主权项

1. A composition comprising:
(a) a drug in a pharmaceutically acceptable form that is a crystalline highly soluble salt form other than the crystalline hydrochloride salt, wherein the crystalline highly soluble salt form has an aqueous solubility at least 1.25-fold the aqueous solubility of the more soluble of the crystalline free base and the crystalline hydrochloride salt forms of the drug; and (b) a concentration-enhancing polymer,wherein said drug alone has an aqueous solubility of up to 2 mg/mL at pH 1 to 8; and said composition is not a molecular dispersion.