发明名称 |
Use of stem cells or progenitor cells to treat, delay, prevent, or repair tearing of cruciate ligaments |
摘要 |
Methods for treating a partial or complete rupture of cranial cruciate ligament (CrCL) damage and for preventing or delaying CrCL damage with or without synovitis in dogs are disclosed. For example, this document provides methods for using stem cells and/or progenitor cells to prevent or reduce the likelihood of CrCL rupture in the contralateral leg of mammals, especially dogs, diagnosed with CrCL rupture, as well as methods for using stem cells and/or progenitor cells to treat, delay or prevent complete CrCL rupture in mammals, especially dogs, diagnosed as having a partial CrCL rupture. |
申请公布号 |
US9457051(B2) |
申请公布日期 |
2016.10.04 |
申请号 |
US201414161291 |
申请日期 |
2014.01.22 |
申请人 |
Animal Cell Therapies, Inc. |
发明人 |
Petrucci Kathryn |
分类号 |
A01N63/00;A01N65/00;A61K35/28 |
主分类号 |
A01N63/00 |
代理机构 |
Pillsbury Winthrop Shaw Pittman LLP |
代理人 |
Pillsbury Winthrop Shaw Pittman LLP |
主权项 |
1. A method for reducing the likelihood of cranial cruciate ligament (CrCL) rupture in a contralateral normal, unaffected leg of a dog diagnosed with an existing or previous unilateral CrCL rupture, or stifle synovitis with or without instability in an opposing leg, the method comprising administering a composition comprising mesenchymal stem cells (MSCs) or progenitor cells to the contralateral normal, unaffected leg of the dog, wherein the composition is administered either intravenously or directly into an area of the CrCL in the contralateral leg. |
地址 |
San Diego CA US |