| 摘要 |
The present invention is related to benzimidazole acetonitriles as well as to pharmaceutical formulations containing such benzimidazole acetonitriles of formula (I). Said benzimidazole acetonitriles are useful in the treatment of metabolic disorders mediated by insulin resistance or hyperglycemia, comprising diabetes type II, inadequate glucose tolerance, insulin resistance, obesity, polycystic ovary syndrome (PCOS) (I). The present invention is furthermore related to methods of preparing benzoxazole acetonitriles. G is pyrimidinyl; L is an amino group, or a 3-8 membered heterocycloalkyl, containing at least one heteroatom selected from N, O, S or L is an acylamino moiety; R<SUP>1 </SUP>is selected from the group comprising or consisting of hydrogen, sulfonyl, amino, carboxy, aminocarbonyl, C<SUB>1</SUB>-C<SUB>6</SUB>-alkyl, C<SUB>2</SUB>-C<SUB>6</SUB>-alkenyl, C<SUB>2</SUB>-C<SUB>6</SUB>-alkynyl or C<SUB>1</SUB>-C<SUB>6</SUB>-alkoxy, aryl, halogen, cyano or hydroxy; R<SUP>2 </SUP>is selected from the group comprising or consisting of hydrogen, C<SUB>1</SUB>-C<SUB>6</SUB>-alkyl, C<SUB>2</SUB>-C<SUB>6</SUB>alkenyl, C<SUB>2</SUB>-C<SUB>6</SUB>-alkynyl, or C<SUB>1</SUB>-C<SUB>6</SUB>-alkoxy.
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