MICELLE COMPOSITIONS AND PROCESS FOR THE PREPARATION THEREOF

摘要

The present invention relates to a micelle composition comprising a hydrophobic compound and an amphiphilic block copolymer, wherein the amphiphilic block copolymer consists of a hydrophobic block A and a hydrophilic block B, the hydrophobic block A comprises at least one hydrophobic polymeric unit X and the hydrophilic block B comprises at least one hydrophilic polymeric unit Y whereby the X and Y blocks alternate.;The present invention further relates to a process for the preparation of the micelle composition wherein the process comprises the steps of:
a) dissolving the hydrophobic compound and the amphiphilic block copolymer in an organic solvent to form a solution,b) adding said organic solution into an aqueous medium,c) optionally repeating aforementioned steps.;The micelle composition according to the present invention is useful in medical applications such as therapeutic cardiovascular applications, veterinary applications, food processing applications, flame retardant applications, coatings, adhesives and cosmetics, fabric/textiles, industrial and art applications.

主权项

1. A micelle composition comprising an amphiphilic triblock copolymer containing a hydrophobic block A and a hydrophilic block B, wherein
a ratio R of the number average molecular weight (Mn) of block A (Mn A) divided to the number average molecular weight of block B (Mn B) is higher than 0.95, and wherein the amphiphilic block copolymer is characterised by a parameter α wherein;
3<α<5.5;α=Mn A/(Mn A+Mn B)×Ko/w A×√Mtot in whichMn A=number average molecular weight (Mn) of block A;Mn B=number average molecular weight (Mn) of block B;Ko/w A=octanol/water partition coefficient of the monomeric units of hydrophobic block A; andMtot=MA+MB, wherein Mtot is expressed in kDa, and wherein the hydrophobic block A comprises at least one hydrophobic polymer X and the hydrophilic block B comprises at least one hydrophilic polymer Y.