| 发明名称 |
METHODS FOR TREATMENT OF OVARIAN CANCER |
| 摘要 |
Provided herein are methods of identifying a subpopulation of ovarian cancer patients who would be responsive to treatment regimens that target folate receptor alpha (FRA)-expressing ovarian tumors and methods of treatment of such patients using an anti-FRA therapeutic agent, such as an antigen-binding protein (e.g., antibody or antigen-binding fragment thereof) that specifically binds to FRA. Also provided are related kits for identification and treatment of the subpopulation of ovarian cancer patients. |
| 申请公布号 |
US2016311921(A1) |
申请公布日期 |
2016.10.27 |
| 申请号 |
US201414898905 |
申请日期 |
2014.06.20 |
| 申请人 |
MORPHOTEK ,INC. |
发明人 |
SCHWEIZER Charles;O'SHANNESSY Daniel John |
| 分类号 |
C07K16/30;G01N33/574;A61K9/00;A61K45/06;A61K49/00;A61K39/395 |
主分类号 |
C07K16/30 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for identifying a subject having a folate receptor alpha (FRA)-expressing ovarian cancer that will be responsive to treatment with an anti-FRA therapeutic agent, said method comprising determining a baseline level of cancer antigen 125 (CA125) of said subject; wherein a baseline CA125 level that is less than about eight times the upper limit of normal (ULN) for CA125 is indicative of a subject who would benefit from treatment with an anti-FRA therapeutic agent. |
| 地址 |
Exton PA US |
