| 摘要 |
Methods for treating and reducing the progression of neurodegenerative diseases, including, without limitation Alzheimer's disease, are provided. The methods of the invention reduce or deplete neutrophil/myeloid cells in the region of the brain by blocking neutrophil/myeloid cell adhesion and interaction with the vascular endothelium, by blocking infiltration of neutrophil/myeloid cells into the brain, by reducing motility of neutrophil/myeloid cells in the parenchyma, by blocking A&bgr;-induced activation and adhesion of neutrophil/myeloid cells, and/or by blocking A&bgr;-induced integrin activation, degranulation and/or ROS release in neutrophil/myeloid cells. |
