System And Method Of Conducting In Silico Clinical Trials

摘要

Described herein are computer systems and methods for generating, in silico, one or more virtual patients. The one or more virtual patients can be used, for example, to conduct a virtual clinical trial, such as to determine an efficacy of a therapy or medical device. The one or more virtual patients mathematically represent a physiological system in an actual patient for a health condition. Also, the one or more virtual patients can be used, for example, to determine an adverse effect from a therapy or any other deviation from a therapy, or compliance of a patient suffering from a health condition on a therapeutic protocol.

主权项

1. A method for determining efficacy of a therapy, comprising:
a) generating in silico a plurality of virtual patients for modeling a health condition based on data collected from a population of previously treated patients;
wherein the collected data represents at least one measured biological response of said previously treated patients to a previously administered therapeutic regimen; b) applying a simulated therapy to said virtual patients; and c) determining one or more physiological parameters in said virtual patients in response to said simulated therapy.