主权项 |
1. A compound represented by the following structural formula, or a pharmaceutically acceptable salt or prodrug thereof, wherein: n is 1, 2 or 3; m is 0 or 1; p is 0 or 1; t is 0, 1 or 2; y is 1 or 2; z is 0, 1 or 2; E is S, O, NH, NOH, NNO2, NCN, NR, NOR or NSO2R; X1 is CR1 when m is 1 or N when m is 0; X2 is O, —NH, —CH2—, SO2, NH—SO2; CH(C1-C6) alkyl or —NR2; X3 is O, —NH, —CH2—, CO, —CH(C1-C6) alkyl, SO2NH, —CO—NH— or —NR3; X4 is CR4R5, CH2CR4R5 or CH2—(C1-C6) alkyl-CR4R5; X5 is a direct bond, O, S, SO2, CR4R5; (C1-C6)alkyl, (C1-C6)alkyloxy, (C1-C6)alkenyl, (C1-C6)alkenyloxy; R is (C6-C12)aryl, (C2-C9)heteroaryl, (C1-C6)alkyl, (C2-C9)heteroaryl(C1-C6)alkyl; R1 is H, CN, (C1-C6)alkylcarbonyl, or (C1-C6)alkyl; R2 and R3 are each independently —H, (C1-C6)alkyl optionally substituted by one or more substituents selected from the group consisting of halogen, (C1-C6)alkyl, (C6-C12)aryl, (C2-C9)heteroaryl, (C1-C6)alkyl(C6-C12)aryl, halo(C6-C12)aryl, and halo(C2-C9)heteroaryl, or optionally when X2 is —NR2 and X3 is —NR3, R2 and R3 may be taken together with the nitrogen atoms to which they are attached form a non-aromatic heterocyclic ring optionally substituted by with one or more substituents selected from halogen, (C1-C6)alkyl, (C6-C12)aryl, (C2-C9)heteroaryl, (C1-C6)alkyl(C6-C12)aryl, halo(C6-C12)aryl, and halo(C2-C9)heteroaryl; R4 and R5 are independently selected from H, (C1-C6)alkyl, or taken together with the carbon to which they are attached to form a spiro (C3-C10)cycloalkyl ring or spiro (C3-C10)cycloalkoxy ring; R6 is —H, halogen, —CN, (C6-C12)aryl, (C6-C12)aryloxy, (C1-C6)alkyloxy; (C1-C6)alkyl optionally substituted by one to four halo or (C1-C6)alkyl; A1 is (C2-C6)alkynyl; (C3-C10)cycloalkyl, (C6-C12)aryl, (C2-C9)heteroaryl, (C2-C9)heterocycloalkyl or benzo(C2-C9)heterocycloalkyl optionally substituted with one or more substituents selected from the group consisting of halo, (C1-C6)alkyl optionally substituted by one to three halo; (C1-C6)alkenyl, amino, (C1-C6)alkylamino, (C1-C6)dialkylamino, (C1-C6)alkoxy, nitro, CN, —OH, (C1-C6)alkyloxy optionally substituted by one to three halo; (C1-C6)alkoxycarbonyl, and (C1-C6) alkylcarbonyl; A2 is H, (C3-C10)cycloalkyl, (C6-C12)aryl, (C2-C9)heteroaryl, (C2-C9)heterocycloalkyl or benzo(C2-C9)heterocycloalkyl optionally substituted with one or more substituents selected from the group consisting of halo, (C1-C6)alkyl optionally substituted by one to three halo; (C1-C6)alkylenyl, amino, (C1-C6) alkylamino, (C1-C6)dialkylamino, (C1-C6)alkoxy, O(C3-C6 cycloalkyl), (C3-C6) cycloalkoxy, nitro, CN, OH, (C1-C6)alkyloxy optionally substituted by one to three halo; (C3-C6) cycloalkyl, (C1-C6) alkoxycarbonyl, (C1-C6) alkylcarbonyl, (C1-C6) haloalkyl; with the proviso that the sum of n+t+y+z is not greater than 6; with the proviso that when p is 0; X2 is NH—SO2 and X3 is NH; with the proviso that when n is 1; t is 0; y is 1; z is 1; X2 is NH; E is O; X3 is NH; A2 is H and X5 is a direct bond; A1 is not unsubstituted phenyl, halophenyl or isopropenyl phenyl; with the proviso that when n is 1; t is 0; y is 1; z is 1; X2 is O; E is O; X3 is NH; A1 is (C6-C12)aryl and X5 is a direct bond; A2 is H and R4 is H then R5 is not cyclohexyl; and with the proviso that when n is 1; t is 0; y is 1; z is 1; X2 is NH; E is O; X3 is CH2; R4 and R5 are both hydrogen; A2 is H and X5 is a direct bond; then A1 is not unsubstituted phenyl. |