发明名称 |
OPIOID KETAL COMPOUNDS AND USES THEREOF |
摘要 |
This invention relates to opioid ketal compounds of Formula (I), Formula (II), or Formula (III): or a pharmaceutically acceptable salts thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently H or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl. The invention also relates to oxycodone ketal compounds of Formula (IV) or (V): or a pharmaceutically acceptable salts thereof. The invention also relates to the use of such compounds for the treatment, prevention, or amelioration of pain.; |
申请公布号 |
US2016244459(A1) |
申请公布日期 |
2016.08.25 |
申请号 |
US201414893224 |
申请日期 |
2014.05.23 |
申请人 |
KUPPER Robert J.;GLOWAKY Raymond C. |
发明人 |
KUPPER Robert J.;GLOWAKY Raymond C. |
分类号 |
C07D489/08 |
主分类号 |
C07D489/08 |
代理机构 |
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代理人 |
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主权项 |
1. A compound of Formula I: or a pharmaceutically acceptable salt thereof, wherein R1 is H or CH3, R2 is H or OH, n is 0, 1, 2 or 3, R3 and R4 are independently H or optionally substituted C1-C4 alkyl, or when n is 0, then R3 and R4 and the carbon atoms to which they are attached together form a five, six, or seven membered ring, which is optionally mono or disubstituted by C1-C4 alkyl, and wherein the carbon atoms labeled * and ** are independently in the R or S configuration. |
地址 |
Warwick RI US |