METHOD FOR CONNECTING SCAFFOLD STRUCTURES FOR TISSUE ENGINEERING APPLICATIONS, IMPLANTS AND TRANSPLANTS IN SURGERY BY MEANS OF LAYER-BY-LAYER METHODS

摘要

1. Method for connecting scaffold structures for tissue engineering applications, implants and transplants in surgery by means of layer-by-layer methods. 2.1 In tissue engineering applications, the ideal tissue adhesive should secure the relevant construct in the wound bed and facilitate, and if possible, promote the integration of the implant or transplant into the surrounding healthy tissue. In doing this, the tissue adhesive must not hinder the natural healing processes. 2.2 The solution according to the invention allows the targeted production of modular tissue constructs by the connection of porous membranes, woven fibres, pressed or sponge-type structures, particles or hydrogels with the aid of layer-by-layer (LbL) methods. Said method according to the invention of combining porous scaffold structures, membranes, structures consisting of woven fibres or pressed structures, particles and hydrogels, in a modular manner, to form complex tissue constructs, and of transferring these into tissue defects, is based on the coating of said shaped bodies with polyelectrolyte multilayers (PEM) which allow the adherence or bonding of neighbouring shaped bodies by chemical or biochemical processes. 3. The invention relates to the use of tissue adhesives in surgery, tissue engineering and regenerative medicine.