摘要 |
<p>An in vivo biological stain composition has a high ratio (at least 6:1) of the conformational isomers of TBO to their N-demethylation derivatives and/or a high ratio (at least 2.5:1) of the 2-methyl conformational isomer of TBO and its N- and N,N-demethylation derivatives to the 4-methyl conformational isomer of TBO and its N- and N,N-demethylation derivatives, and/or a high concentration (at least 95%) of said conformational isomers and N-demethylation derivatives in the organic dye content of the composition and/or a high concentration (at least 50%) of said 2-methyl conformational isomer in the organic dye content of the composition. Processes are provided for manufacture and analysis of these TBO products, which are used for detecting dysplastic oral tissue. <IMAGE></p> |