LYOPHILIZED RECOMBINANT VWF FORMULATIONS

摘要

PROBLEM TO BE SOLVED: To provide stable pharmaceutical formulations comprising recombinant von-Willebrand Factor (rVWF).SOLUTION: The present invention provides formulations useful for lyophilization of recombinant VWF, resulting in a highly stable pharmaceutical composition. The stable pharmaceutical composition is useful as a therapeutic agent in the treatment of individuals suffering from disorders or conditions that can benefit from the administration of recombinant VWF. In one embodiment, a stable lyophilized pharmaceutical formulation of recombinant rVWF is provided comprising: (a) a rVWF; (b) one or more buffering agents; (c) one or more amino acids; (d) one or more stabilizing agents; and (e) one or more surfactants.SELECTED DRAWING: None