发明名称 |
Isolated antibody which specifically binds to PCSK9 |
摘要 |
The present invention provides antagonizing antibodies, antigen-binding portions thereof, and aptamers that bind to proprotein convertase subtilisin kexin type 9 (PCSK9). Also provided are antibodies directed to peptides, in which the antibodies bind to PCSK9. The invention further provides a method of obtaining such antibodies and antibody-encoding nucleic acid. The invention further relates to therapeutic methods for use of these antibodies and antigen-binding portions thereof to reduce LDL-cholesterol levels and/or for the treatment and/or prevention of cardiovascular disease, including treatment of hypercholesterolemia.
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申请公布号 |
US8080243(B2) |
申请公布日期 |
2011.12.20 |
申请号 |
US20090558312 |
申请日期 |
2009.09.11 |
申请人 |
LIANG HONG;ABDICHE YASMINA NOUBIA;CHAPARRO RIGGERS JAVIER FERNANDO;GOMES BRUCE CHARLES;HAWKINS JULIE JIA LI;PONS JAUME;WANG YULI;RINAT NEUROSCIENCE CORP.;PFIZER INC. |
发明人 |
LIANG HONG;ABDICHE YASMINA NOUBIA;CHAPARRO RIGGERS JAVIER FERNANDO;GOMES BRUCE CHARLES;HAWKINS JULIE JIA LI;PONS JAUME;WANG YULI |
分类号 |
A61K39/395 |
主分类号 |
A61K39/395 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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