ARYLSULFONYLMETHYL OR ARYLSULFONAMIDE SUBSTITUTED AROMATIC COMPOUNDS SUITABLE FOR TREATING DISORDERS THAT RESPOND TO MADULATION OF THE DOPAMINE D3 RECEPTOR

摘要

The present invention relates to aromatic compounds of the formula (I), wherein Ar is phenyl or an aromatic 5- or 6-membered C-bound heteroaromatic radical, wherein Ar may carry 1 radical R^a and wherein Ar may also carry 1 or 2 radicals R^b; X is N or CH; Y is O, S, -CH=N-, -CH=CH- or -N=CH-; A is CH_2i O or S; E is CR⁶R⁷ or NR ³; R¹ is C₁-C₄-alkyl, C₃-C₄-cycloalkyl, C₃-C4-cycloalkylmethyl, C₃-C₄-alkenyl, fluorinated C₁-C₄-­alkyl, fluorinated C₃-C₄-cycloalkyl, fluorinated C₃-C₄-cycloalkylmethyl, fluorinated C₃-C₄­-alkenyl, formyl or C,-C₃-alkylcarbonyl; R^1a is H, C₂-C₄-alkyl, C₃-C₄-cycloalkyl, C₃-C₄-alkenyl, fluorinated C₁-C₄-alkyl, fluorinated C₃-C₄ -cycloalkyl, or R^1a and R² together are (CH₂)_n with n being 2 or 3, or R₁