| 主权项 |
1. A compound of Formula I or a pharmaceutically acceptable salt, or a stereoisimer thereof: A is selected from aryl, heteroaryl, cycloalkylC(0-10)alkyl, C1-6alkyl; R2 and R3 are each independently selected from hydrogen, C1-4alkyl and hydroxy, wherein R2 and R3 may optionally, join together with the carbon they are attached to form a 3 to 6 membered ring; X1 is C; X2, X3, and X4 are each independently selected from O, N, S, and C and provided that the formed ring system contains 0, 1, 2, or 3 atoms selected from O, N and S; n is 0, 1, 2, 3 or 4; m is 0, 1, 2, 3 or 4; p is 0, 1, 2, 3, or 4; R4 is selected from:
halogen,oxo (═O),C1-10 alkyl(oxy)0-1 (carbonyl)0-1C0-10 alkyl,C1-10 heteroalkyl(oxy)0-1 (carbonyl)0-1C0-10 alkyl,C2-10 alkenyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,aryl C0-10 alkyl(oxy)0-1 (carbonyl)0-1C0-10 alkyl,C3-12 cycloalkyl C0-10 alkyl(oxy)0-1 (carbonyl)0-1C0-10 alkyl,heteroaryl C0-10 alkyl(oxy)0-1 (carbonyl)0-1C0-10 alkyl,(C3-12)heterocycloalkyl C0-10 alkyl(oxy)0-1 (carbonyl)0-1C0-10 alkyl,C0-10 alkyl(oxy)0-1 (carbonyl)0-1 aminoC0-10 alkyl,C1-10 alkylamino(carbonyl)0-1C0-10alkyl,(C1-10)heteroalkyl(oxy)0-1 (carbonyl)0-1 amino C0-10 alkyl,(C1-10)heteroalkylamino(carbonyl)0-1 C0-10alkyl,C3-12 cycloalkyl C0-10 alkylaminoC0-10 alkyl,aryl C0-10 alkylaminoC0-10 alkyl,heteroaryl C0-10 alkylaminoC0-10 alkyl,(C3-12)heterocycloalkyl C0-10 alkylaminoC0-10 alkyl,C1-10 alkylsulfonyl,C1-10 heteroalkylsulfonyl,(C3-12)cycloalkylC0-10alkylsulfonyl,(C3-12)cycloheteroalkylC0-10alkylsulfonyl,heteroarylC0-10 alkylsulfonyl,arylC0-10 alkylsulfonyl,—SO2NH2,—SO2NH(C1-6alkyl),—SO2N(C1-6alkyl)2,C0-10 alkylsulfamoyl,C1-10 heteroalkylsulfamoyl,(C3-12)cycloalkylC0-10 alkylsulfamoyl,(C3-12)cycloheteroalkylC0-10 alkylsulfamoyl,heteroarylC0-10 alkylsulfamoyl,arylC0-10 alkylsulfamoyl,C0-10 alkylsulfonimidoylC0-10 alkyl,C1-10 heteroalkylsulfonimidoylC0-10 alkyl,(C3-12)cycloalkylC0-10 alkylsulfonimidoylC0-10 alkyl,(C3-12)cycloheteroalkylC0-10alkylsulfonimidoylC0-10 alkyl,heteroarylC0-10 alkylsulfonimidoylC0-10 alkyl,arylC0-10 alkylsulfonimidoylC0-10 alkyl,(C1-10 alkyl)1-2amino,—CO2(C0-10 alkyl),—(C0-10 alkyl)CO2H,—SO2CF3,—SO2CF2H,—SO2CH2CF3,C1-10 alkylsulfinyl,C1-4acylaminoC0-10 alkyl,hydroxy,—(C1-10 alkyl)OH,C1-10 alkoxyC0-10 alkyl,cyano,(C1-6alkyl)cyano, andC1-6haloalkyl, wherein two R4 together with the ring atom to which each is attached optionally may form a saturated ring; R5 is selected from:
halogen,oxo (═O),C1-10 alkyl(oxy)0-1 (carbonyl)0-1 C0-10 alkyl,C1-10 heteroalkyl(oxy)0-1 (carbonyl)0-1 C0-10 alkyl,C2-10 alkenyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,aryl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,C3-12 cycloalkyl C0-10 alkyl(oxy)0-1 (carbonyl)0-1 C0-10 alkyl,heteroaryl C0-10 alkyl(oxy)0-1 (carbonyl)0-1 C0-10 alkyl,(C3-12)heterocycloalkyl C0-10 alkyl(oxy)0-1 (carbonyl)0-1 C0-10 alkyl,C0-10 alkylaminocarbonylC0-1 alkyl,C0-10 alkyl(oxy)0-1 (carbonyl)0-1 aminoC0-10 alkyl,(C1-10)heteroalkyl(oxy)0-1(carbonyl)0-1 aminoC0-10 alkyl,C3-12 cycloalkyl C0-10 alkylaminoC0-10 alkyl,aryl C0-10 alkylaminoC0-10 alkyl,heteroaryl C0-10 alkylaminoC0-10 alkyl,(C3-12)heterocycloalkyl C0-10 alkylaminoC0-10 alkyl,(C1-10 alkyl)1-2 amino,—SF5,C0-10 alkylsulfonyl,C1-10 heteroalkylsulfonyl,(C3-12)cycloalkylC0-10alkylsulfonyl,(C3-12)cycloheteroalkylC0-10 alkylsulfonyl,heteroarylC0-10 alkylsulfonyl,arylC0-10 alkylsulfonyl,C0-10 alkylsulfamoyl,C1-10 heteroalkylsulfamoyl,(C3-12)cycloalkylC0-10 alkylsulfamoyl,(C3-12)cycloheteroalkylC0-10 alkylsulfamoyl,heteroarylC0-10 alkylsulfamoyl,C0-10 alkylsulfonimidoylC0-10 alkyl,C1-10 heteroalkylsulfonimidoylC0-10 alkyl,(C3-12)cycloalkylC0-10 alkylsulfonimidoylC0-10 alkyl,(C3-12)cycloheteroalkylC0-10alkylsulfonimidoylC0-10 alkyl,heteroarylC0-10 alkylsulfonimidoylC0-10 alkyl,arylC0-10 alkylsulfonimidoylC0-10 alkyl,—SO2NH2,—SO2NH(C1-6alkyl),—SO2N(C1-6alkyl)2,arylC0-10 alkylsulfamoyl,(C0-10 alkyl)1-2 amino,—CO2(C0-10 alkyl),—(C0-10 alkyl)CO2H,—SO2CF3,—SO2CF2H,—SO2CH2CF3,C1-10 alkylsulfinyl,C1-4acylaminoC0-10 alkyl,hydroxy,—(C1-10 alkyl)OH,C1-10 alkoxyC0-10 alkyl,cyano,(C1-6alkyl)cyano, andC1-6haloalkyl; and wherein R4 and R5 are each optionally substituted with 1, 2, 3, or 4 R6 substituents and R6 is independently selected from:
halogen,C1-10 alkyl(oxy)0-1 (carbonyl)0-1C0-10 alkyl,C1-10 heteroalkyl(oxy)0-1 (carbonyl)0-1C0-10 alkyl,C2-10 alkenyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,aryl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,C3-12 cycloalkyl C0-10 alkyl(oxy)0-1 (carbonyl)0-1C0-10 alkyl,heteroaryl C0-10 alkyl(oxy)0-1 (carbonyl)0-1C0-10 alkyl,(C3-12)heterocycloalkyl C0-10 alkyl(oxy)0-1(carbonyl)0-1C0-10 alkyl,C1-10 alkyl(carbonyl)0-1oxyC0-10 alkyl,C2-10 alkenyl(carbonyl)0-1 oxyC0-10 alkyl,C1-10 heteroalkyl(carbonyl)0-1 oxyC0-10 alkyl,aryl C0-10 alkyl (carbonyl)0-1oxyC0-10 alkyl,(C3-12)cycloalkyl C0-10 alkyl(carbonyl)0-1 oxyC0-10 alkyl,heteroarylC0-10 alkyl(carbonyl)0-1 oxyC0-10 alkyl,(C3-12)heterocycloalkyl C0-10 alkyl(carbonyl)0-1 oxyC0-10 alkyl,((C0-10)alkyl)1-2aminocarbonyloxy,aryl (C0-10)alkylaminocarbonyloxy,—CO2(C0-10 alkyl),—(C0-10 alkyl)CO2H,oxo (═O),C0-10 alkylsulfonyl,C1-10 heteroalkylsulfonyl,(C3-12) cycloalkylsulfonyl,(C3-12) cycloheteroalkylsulfonyl,heteroarylsulfonyl,arylsulfonyl,aminosulfonyl,—SO2NH2,—SO2NH(C1-6alkyl),—SO2N(C1-6alkyl)2,—SO2CF3,—SO2CF2H,C1-10 alkylsulfinyl,amino,(C1-10 alkyl)1-2amino,-(oxy)0-1 (carbonyl)0-1N(C0-10 alkyl)1-2 C1-4acylaminoC0-10 alkyl,hydroxy,(C1-10 alkyl)OH,C1-10 alkoxyC0-10 alkyl,(C1-10 alkyl)cyano,cyano, andC1-6haloalkyl; and R6 is optionally substituted with 1, 2, or 3 R7 substituents selected from hydrogen, hydroxy, (C1-6)alkyl, C1-10 alkoxyC0-10 alkyl, (C1-10 alkyl)OH, halogen, CO2H, —(C0-6)alkylCN, —O(C═O)C1-C6 alkyl, NO2, trifluoromethoxy, trifluoroethoxy, trifluoromethyl, trifluoroethyl, —N—C(O)O(C0-6)alkyl, C1-10 alkylsulfonyl, oxo (O═), aminosulfonyl, —SO2C1-6alkyl, —SO2CF3, —SO2CF2H, —C1-10 alkylsulfinyl, —O(0-1)(C1-10)halo, —SO2NH2, —SO2NH(C1-6alkyl), —SO2N(C1-6alkyl)2, alkyl, amino(C1-6alkyl)0-2 and NH2. |
