METHODS AND TRANSGENIC PLANTS FOR THE PRODUCTION OF PLANT-PRODUCED GLYCOPOLYPEPTIDE MULTIMERS

摘要

The present invention contemplates a transgenic plant having somatic and germ cells containing at least two mammalian genes coding for polypeptides capable of autogenously associating with each other to form a biologically active multimer. The present invention also contemplates glycopolypeptide multimers having a polypeptide that contains an immunoglobulin amino acid residue sequence and an oligosaccharide that comprises a core pentasaccharide and N-acetylglucosamine-containing outer branches, such that the multimer is free from sialic acid. The production of passive immunity against a preselected antigen by administering a sialic acid free glycopolypeptide multimer to an animal is also contemplated.