发明名称 |
THERAPEUTIC AGENTS FOR THE TREATMENT OF DISEASES ASSOCIATED WITH UNDESIRED CELL PROLIFERATION |
摘要 |
The invention is based on observing that LIF is capable of activating the self-renewal of tumor stem cells in cancer, in particular gliomas, which indicates that the inhibition of LIF, and generally of IL-6 type cytokines, can be used in therapeutic compositions for the treatment of diseases associated with unwanted proliferation. The invention also relates to a method for the identification of compounds capable of blocking/inhibiting the proliferation of stem cells, and to an in vitro method for the diagnosis of diseases associated with unwanted cell proliferation in a subject or for determining the predisposition of a subject to suffer said disease associated with unwanted cell proliferation, or for prognosis of average life expectancy of subjects suffering from said tumors. |
申请公布号 |
EP3045474(A3) |
申请公布日期 |
2016.09.28 |
申请号 |
EP20160155009 |
申请日期 |
2010.04.06 |
申请人 |
FUNDACIÓ PRIVADA INSTITUCIÓ CATALANA DE RECERCA IESTUDIS AVANÇATS;FUNDACIÓ PRIVADA INSTITUT D'INVESTIGACIÓ ONCOLÒGICA DE VALL D'HEBRON;FUNDACIÓ PRIVADA INSTITUT DE RECERCA HOSPITAL UNIVERSITARI VALL HEBRON |
发明人 |
SEOANE SUÁREZ, JOAN;PEÑUELAS PRIETO, SILVIA;BASELGA TORRES, JOSÉ |
分类号 |
C07K16/24;A61K39/00;A61K39/395 |
主分类号 |
C07K16/24 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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