发明名称 |
Viral recombinant pseudo-particles and vaccinal and anti-tumoral applications |
摘要 |
Viral recombinant pseudo-particles characterized in that they are formed by self-assembly of at least one protein having a viral structure, in that they have a size comprised between about 20 and 60 nm, in that they form an approximately icosahedral structure, an in that said protein is modified by the presence of at least one epitope comprising a sequence from 8 to 25 amino acids which is susceptible of association to at least one molecule of class I and/or II of the major histocompatibility complex, with the exclusion of the epitope C3:T, said association being recognized by cytotoxic lymphocytes TCD8<+> and/or TCD4<+>. Said pseudo-particles may be used as anti-viral vaccines or as medicaments. |
申请公布号 |
AU6933296(A) |
申请公布日期 |
1997.07.28 |
申请号 |
AU19960069332 |
申请日期 |
1996.08.30 |
申请人 |
INSTITUT PASTEUR;IMMUNOLOGIA Y GENETICA APLICADA S.A. |
发明人 |
IGNACIO CASAL;CHRISTINE SEDLIK;JAVIER SARRASECA;CLAUDE LECLERC;RICHARD LO MAN;PALOMA RUEDA |
分类号 |
C12N15/00;A61K31/00;A61K35/76;A61K39/00;A61K39/12;A61K39/23;A61K39/29;A61K39/295;A61P31/00;A61P31/12;A61P31/14;A61P31/20;A61P37/00;A61P37/04;C07K14/015;C07K14/02;C07K14/08;C12N5/10;C12N15/33;C12N15/35;C12N15/36;C12N15/40;C12P21/02 |
主分类号 |
C12N15/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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