METHODS OF PREVENTING PLATELET ALLOIMMUNIZATION AND ALLOIMMUNE PLATELET REFRACTORINESS AND INDUCTION OF TOLERANCE IN TRANSFUSED RECIPIENTS

摘要

Methods and compositions for the prevention or reduction of platelet transfusion associated complications are provided. Methods are provided to modify donor whole blood or platelets prior to transfusion to prevent or reduce alloimmune platelet refractoriness.

主权项

1. A method for reducing a recipient's risk of developing platelet alloimmunization upon receiving transfused donor platelets comprising the steps of:
filtering whole blood from a donor through a leukoreduction filter; performing pathogen reduction on the whole blood by adding riboflavin to the whole blood and irradiating the whole blood and riboflavin with UV light; and transfusing the filtered and pathogen reduced whole blood into a recipient, wherein the transfused whole blood has an acceptance rate of 80% or higher; thereby reducing the risk of the recipient developing platelet alloimmunization upon receiving transfused donor platelets.