发明名称 Novel reagents and method for conjugating biological molecules
摘要 <p>The invention relates to a process for the conjugation of a molecule containing a thiol or amino group to a polymer, which comprises reacting said molecule with a compound of the general formula: €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ X-[Q-W-(CH=CH) n -CH=CH 2 ] m €ƒ€ƒ€ƒ€ƒ€ƒ(V) in which X represents a polymer; Q represents a linking group; W represents a keto group or an ester group -O-CO-; n represents 0 or an integer of from 1 to 4; and m represent an integer of from 1 to 8. The invention also relates to a compound of the general formula €ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ€ƒ X-[NH-CO-Ar-W-(CH=CH) n -CH=CH 2 ] m €ƒ€ƒ€ƒ€ƒ€ƒ(Va) in which X, W, n and m have the meanings given above; and Ar represents an unsubstituted or substituted aryl group.</p>
申请公布号 AU2009275358(A1) 申请公布日期 2010.01.28
申请号 AU20090275358 申请日期 2009.07.17
申请人 POLYTHERICS LIMITED 发明人 ANTHONY GODWIN
分类号 A61K47/48 主分类号 A61K47/48
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