摘要 |
A tubular tissue graft device is provided comprising a tubular member and a restrictive fiber matrix of a bioerodible polymer about a circumference of the tubular tissue. The matrix may be electrospun onto the tubular tissue. In one embodiment, the tubular tissue is from a vein, such as a saphenous vein, useful as an arterial graft, for example and without limitation, in a coronary artery bypass procedure. 5 Also provided is method of preparing a tubular graft comprising depositing a fiber matrix of a bioerodible polymer about a perimeter of a tubular tissue to produce a tubular tissue graft device. A cardiac bypass method comprising bypassing a coronary artery with a tubular tissue graft device comprising a vein and a restrictive fiber matrix of a bioerodible polymer about a circumference of the vein also is provided. |
申请人 |
Neograft Technologies, Inc.;University of Pittsburgh-of the Commonwealth System of Higher Education |
发明人 |
El-Kurdi, Mohammed;Flaherty, J. Christopher;Hong, Yi;McGrath, Jonathan;Soletti, Lorenzo;Stankus, John;Vorp, David;Wagner, William |