发明名称 |
THIN FILM CELL ENCAPSULATION DEVICES |
摘要 |
Thin film devices, e.g., multilayer thin film devices, that encapsulate cells for transplantation into a subject are provided. Also provided are methods of using and methods of preparing the subject devices. The thin film devices include a first porous polymer layer and a second porous polymer layer that define a lumen there between and encapsulate a population of cells within the lumen. The thin film devices can promote vascularization into the lumen of the device via the pores in the first polymer layer and/or second polymer layer; limit foreign body response to the device; limit ingress of cells, immunoglobulins, and cytokines into the lumen via the first and the second polymer layers; and release from the first polymer layer and/or the second polymer layer molecules secreted by the population of cells. |
申请公布号 |
WO2016154333(A1) |
申请公布日期 |
2016.09.29 |
申请号 |
WO2016US23808 |
申请日期 |
2016.03.23 |
申请人 |
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA |
发明人 |
DESAI, Tejal A.;NYITRAY, Crystal;CHANG, Ryan |
分类号 |
A61K9/70;A61K9/00;B82Y40/00 |
主分类号 |
A61K9/70 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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