NUCLEOSIDE ARYL PHOSPHORAMIDATES FOR THE TREATMENT OF RNA-DEPENDENT RNA VIRAL INFECTION

摘要

The present invention provides nucleoside aryl phosphoramidates of struct ural formula (I) which are precursors to inhibitors of RNA-dependent RNA vir al polymerase. These compounds are precursors to inhibitors of RNA-dependent RNA viral replication and are useful for the treatment of RNA-dependent RNA viral infection. They are particularly useful as precursors to inhibitors o f hepatitis C virus (HCV) NS5B polymerase, as precursors to inhibitors of HC V replication, and/or for the treatment of hepatitis C infection. The invent ion also describes pharmaceutical compositions containing such nucleoside ar yl phosphoramidates alone or in combination with other agents active against RNA-dependent RNA viral infection, in particular HCV infection. Also disclo sed are methods of inhibiting RNA-dependent RNA polymerase, inhibiting RNA-d ependent RNA viral replication, and/or treating RNA-dependent RNA viral infe ction with the nucleoside aryl phosphoramidates of the present invention. (I )