Dynamic bioactive nanofiber scaffolding

摘要

A resorbable bone graft scaffold material, including a plurality of overlapping and interlocking fibers defining a scaffold structure, plurality of pores distributed throughout the scaffold, and a plurality of glass microspheres distributed throughout the pores. The fibers are characterized by fiber diameters ranging from about 5 nanometers to about 100 micrometers, and the fibers are a bioactive, resorbable material. The fibers generally contribute about 20 to about 40 weight percent of the scaffold material, with the microspheres contributing the balance.

主权项

1. A resorbable bone graft scaffold material, comprising:
a plurality of overlapping and interlinking nonporous, polymer-free bioactive ceramic fibers defining a scaffold structure; a plurality of pores distributed throughout and defined by the scaffold; and a first plurality of first bioactive, resorbable spheres distributed in at least some of the respective pores; wherein each respective first sphere is fused to at least one ceramic fiber; a second plurality of second loose bioactive, resorbable spheres, wherein each respective second loose sphere is not fused to a fiber; wherein the fibers are characterized by fiber diameters ranging from 5 nanometers to 100 micrometers; wherein the fibers are composed of a bioactive, resorbable material.