发明名称 |
PRODUCTION OF GALACTOSYLATED GLYCOPROTEINS IN LOWER EUKARYOTES |
摘要 |
The present invention provides a novel lower eukaryotic host cell producing human-like glycoproteins characterized as having a terminal beta-galactose residue and essentially lacking fucose and sialic acid residues. The present invention also provides a method for catalyzing the transfer of a galactose residue from UDP-galactose onto an acceptor substrate in a recombinant lower eukaryotic host cell, which can be used as a therapeutic glycoprotein. |
申请公布号 |
EP1737969(A2) |
申请公布日期 |
2007.01.03 |
申请号 |
EP20050732293 |
申请日期 |
2005.04.15 |
申请人 |
GLYCOFI, INC. |
发明人 |
DAVIDSON, ROBERT;GERNGROSS, TILLMAN;WILDT, STEFAN;CHOI, BYUNG-KWON;NETT, JUERGEN;BOBROWICZ, PIOTR;HAMILTON, STEPHEN |
分类号 |
C12N9/10;C12N1/18;C12N9/90;C12P21/00;C12P21/06 |
主分类号 |
C12N9/10 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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