| 主权项 |
1. A pharmaceutical composition comprising a pharmaceutically acceptable excipient and a compound of Formula (I):or a salt thereof, wherein
A is an optionally substituted aliphatic, alicyclic, aryl, aralkyl, heteroaliphatic, heterocyclic, or heteroaromatic group; X1 is selected from —O—, —NH—, and —S—, wherein either X1 is —NH— or A is a radical of a non-steroidal anti-inflammatory compound; B is an aliphatic, alicyclic, heteroaliphatic, heterocyclic, aralkyl, or heteroaromatic group optionally substituted with one or more X2 moieties, with the proviso that B is not described by each X2 is, independently, selected from hydrogen, halogen, hydroxyl, alkoxyl, —CN; an optionally substituted aliphatic, alicyclic, heteroaliphatic, heterocyclic, aryl, aralkyl, or heteroaromatic moiety; —ORR, —S(═O)—Rd, —NRbRc, —C(═O)Ra and —C(═O)ORa; n is 0-2; Ra, for each occurrence, is independently selected from hydrogen and an optionally substituted aliphatic, alicyclic, heteroaliphatic, heterocyclic, aryl, aralkyl, or heteroaromatic moiety; each of Rb and Rc, for each occurrence, is independently selected from hydrogen; hydroxyl, SO2Rd, and an aliphatic, alicyclic, heteroaliphatic, heterocyclic, aryl, aralkyl, heteroaromatic or acyl moiety; Rd, for each occurrence, is independently selected from hydrogen, —N(Re)2, aliphatic, aryl and heteroaryl, Re, for each occurrence, is independently hydrogen or aliphatic; and RR is an optionally substituted aliphatic, alicyclic, heteroaliphatic, heterocyclic, aryl, aralkyl, heteroaromatic or acyl moiety; and D is —O—P(O)(ORf)2 or —O—P(ORg)2, wherein each Rf and Rg is a substituted or unsubstituted alkyl of 1-6 carbon atoms. |
