发明名称 |
Transglutaminase mediated conjugation of peptides |
摘要 |
Methods for conjugating peptides are provided comprising i) reacting a peptide with a first compound comprising a functional group in the presence of a transglutaminase capable of incorporating said compound into the peptide to form a transaminated peptide, and ii) reacting said transaminiated peptide with e.g. a functionalised polymer capable of reacting with the functional group incorporated in the peptide in the enzymatic reaction. |
申请公布号 |
AU2005205867(A1) |
申请公布日期 |
2005.08.04 |
申请号 |
AU20050205867 |
申请日期 |
2005.01.18 |
申请人 |
NOVO NORDISK A/S |
发明人 |
FLORENCIO ZARAGOZA DORWALD;MAGALI ZUNDEL;NILS LANGELAND JOHANSEN |
分类号 |
C07K14/61;A61K38/19;A61K38/26;A61K38/27;A61K38/28;A61K38/48;A61K47/48;C07K1/107;C12N9/96;C12P21/00 |
主分类号 |
C07K14/61 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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