| 发明名称 |
MULTIMERIC IL-15 SOLUBLE FUSION MOLECULES AND METHODS OF MAKING AND USING SAME |
| 摘要 |
The present invention features compositions and methods featuring ALT-803, a complex of an interleukin-15 (IL-15) superagonist mutant and a dimeric IL-15 receptor α/Fc fusion protein useful for enhancing an immune response against a neoplasia (e.g., multiple myeloma, melanoma, lymphoma) or a viral infection (e.g., human immunodeficiency virus). |
| 申请公布号 |
US2016213750(A1) |
申请公布日期 |
2016.07.28 |
| 申请号 |
US201615083998 |
申请日期 |
2016.03.29 |
| 申请人 |
Altor Bioscience Corporation |
发明人 |
Wong Hing C.;Rhode Peter;Liu Bai;Zhu Xiaoyun;Han Kai-Ping |
| 分类号 |
A61K38/20;A61K39/395;C07K14/54;C07K16/28;C07K14/715;A61K38/17 |
主分类号 |
A61K38/20 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating neoplasia or virus infection in a subject, the method comprising administering to said subject an effective amount of a pharmaceutical composition comprising IL-15N72D:IL-15RαSu/Fc complex (Alt-803) comprising a dimeric IL-15RαSu/Fc and two IL-15N72D molecules, thereby treating the neoplasia or virus infection. |
| 地址 |
Miramar FL US |
