发明名称 |
Methods and compositions for treating complement-associated disorders using eculizumab |
摘要 |
Disclosed are compositions containing an inhibitor of human complement and use of the compositions in methods for treating or preventing complement-associated disorders. In some embodiments, the inhibitor is chronically administered to patients. In some embodiments, the inhibitor is administered to a patient in an amount and with a frequency to maintain systemic complement inhibition and prevent breakthrough. In some embodiments, the compositions contain an antibody, or antigen-binding fragment thereof, that binds to a human complement component C5 protein or a fragment of the protein such as C5a or C5b. |
申请公布号 |
NZ592786(A) |
申请公布日期 |
2013.02.22 |
申请号 |
NZ20090592786 |
申请日期 |
2009.11.10 |
申请人 |
ALEXION PHARMACEUTICALS, INC. |
发明人 |
ROTHER, RUSSELL, P;BEDROSIAN, CAMILLE;SQUINTO, STEPHEN, P;BELL, LEONARD |
分类号 |
A61K39/00;A61K38/00;C07K16/24 |
主分类号 |
A61K39/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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