发明名称 |
MANIPULATION OF HAIRY AND ENHANCER OF SPLIT 3 (HES3) AND ITS REGULATORS/MEDIATORS IN DIABETES, OBESITY, AND METABOLIC SYNDROME |
摘要 |
The present invention relates to an inhibitor of Hairy and Enhancer of Split 3 (Hes3) for use in a method of preventing or treating (i) a disease characterised by insulin resistance or (ii) obesity. Further, the present invention also relates to a method of preventing or treating a disease characterised by insulin resistance or obesity, to a pharmaceutical composition comprising Hes3 and to Hes3 and/or an activator thereof for use in a method of preventing or treating a disease characterised by decreased insulin production. In addition, the present invention relates to a method of preventing or treating a disease characterised by decreased insulin production and to the use of Hes3 as a target in a screen for identifying a compound suitable as a lead compound and/or as a medicament for the treatment of diseases characterised by insulin resistance or of obesity or of diseases characterised by decreased insulin production. Moreover, the present invention relates to in-vitro or ex-vivo methods for identifying a compound suitable as a lead compound and/or as a medicament for the treatment and/or prevention of diseases characterised by insulin resistance or of obesity or of diseases characterised by decreased insulin production. Finally, the present invention also relates to an in-vitro method of eliciting or enhancing insulin production. |
申请公布号 |
WO2016041906(A3) |
申请公布日期 |
2016.09.01 |
申请号 |
WO2015EP70971 |
申请日期 |
2015.09.14 |
申请人 |
TECHNISCHE UNIVERSITÄT DRESDEN |
发明人 |
ANDROUTSELLIS-THEOTOKIS, Andreas;NIKOLAKOPOULOU, Polyxeni;MASJKUR, Jimmy;POSER, Steven Walter |
分类号 |
C12N15/01;A61K31/713;C07K14/47;C07K14/705;C12N15/11;C12N15/113;G01N33/574;G01N33/68 |
主分类号 |
C12N15/01 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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