摘要 |
This invention relates to novel compounds which are inhibitors of acyl coenzymeA: diacylglycerol acyltransferase 1 (DGAT-1), to pharmaceutical compositions containing them, to processes for their preparation, and to their use in therapy for the prevention or treatment of diseases related to DGAT-1 dysfunction or where modulation of DGAT-1 activity may have therapeutic benefit including but not limited to obesity, obesity related disorders, hypertriglyceridemia, hyperlipoproteinemia, chylomicronemia, dyslipidemia, non-alcoholic steatohepatitis, diabetes, insulin resistance, metabolic syndrome, hepatitis C virus infection and acne or other skin disorders. |
申请人 |
GLAXOSMITHKLINE INTELLECTUAL PROPERTY (NO. 2) LIMITED |
发明人 |
QIN, DONGHUI;CHEUNG, MUI;JOSHI, HEMANT;TANGIRALA, RAGHURAM;BETHI, SRIDHAR REDDY |