PHARMACEUTICAL COMPOSITIONS OF ANGIOTENSIN II RECEPTOR BLOCKERS

摘要

The present invention relates to the methods of increasing the bioavailability of Angiotensin II Receptor Blockers (ARBs) by treating it with at least one absorption augmenting agent. In particular, the present invention relates to use of absorption augmenting agents which results in significant increase in the bioavailability as more drug is present in the absorbable form at the absorption site which is in sharp contrast to the currently marketed ARB formulations. In the composition, the ARB may be present in the form of physical blend, solid dispersion, solid solution or complex with absorption augmenting agent. The composition of an ARB with absorption augmenting agent can be incorporated in a tablet, coated tablet, inlay or bilayer tablet or capsule dosage form for immediate release, sustained release, pulsatile release or modified release.