首页
产品
黄页
商标
征信
会员服务
注册
登录
全部
|
企业名
|
法人/股东/高管
|
品牌/产品
|
地址
|
经营范围
发明名称
Antigen Binding Proteins to Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9)
摘要
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an 5 antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described. WO 2009/026558 PCT/US2008/074097 1-----------------------------------------------50 PCSK9parent (1) OZUNUGOYEiMIIAj '5EdGLAAP$1k5G5A~'iFRIKdPWESPG3YVV PCSK9mutants (1) R _1iRRRR RR FiliRdl lPWfi PdlYVV 51--- pro domain ------------------------------ 100 PCSK9parent (51) VNIIiIT LN NiTKII~if9FINGLLPGFLVf§fd PCSK9mutants (51) V-'Lj lKS! S TgF LKlIAil E-li TKIIAlFiGLLPGFLMEliF L 101-------------------=======50 PCSK9parent (101) ILELAILf LMNiUdYIEEDSSVFISIFINIlEItIPPRYRAf0EidPidGGI4V PCSK9mutants (101) EIL L YEI 1 IlPPRYR lIPIGGV 151================================ -------=== 200 PCSK9parent (151) E EAS CDSI-GTHL PCSK9mutants (151) EVYLLD'II|RRRH|EEEIDGRVRRRERRRERRRRRRERRR CDRqGTHL 201===---=============---=----------= = -====250 PCSK9parent (201) AGVVSG fAGVAINgfMRSI NVLNdGNGtVSGTLIGLEINI!NZ5~QvdB~9 PCSK9mutants (201) AGVVSGFPAGVA lidNlMRSlVLNClG1GlVSGTLIGLElR S P 251================= catalytic domain =========300 PCSK9parent (251) 7PLVVLLPLAGYSIVLtACQ RLIN GVVLVTAAGNF1 DDAC YSPA2A PCSK9mutants (251) 'PLVVLLPLAdlYSEVL lAdARLAEGVVLVTAAGNEEDDACRYSPARA 301============================================------350 PCSK9parent (301) PEVITVGATNQDQP TIGTI4GTNFGRCVDLFAPGEdIIGAS8CSC5' PCSK9mut ants (301) PEVI TVGA TNIRNRP(PMiiliGPGTNFGRCVDLFAPGl 9I I GAS$1 CSI Cli 351-= = = = = = = = = = == = = = = = = = = = = 400 PCSK9parent (351) 5 GSAAVGAIMjA5ILiAIL~ SK9IEEF PCSK9mutants (351) |PSGTAHAI I 401===------------------------------------------450 PCSK9parent (401) INININTPI LVA LPP5TN SG LFCRTVWSS WSRIbAl CAB PCSK9mutants (401) '__RRTALVALPPRRRRRRLFCRTWIS RRRECB 451--------------------------------------------500 PCSK9parent (451) EELLSCSSFSRSGKRRGERMEAQGGKLVCRAHNAFGP2GVYAIARCCLLP PCSK9mutants (451) EELLSCSSFSRSGKRRGERMERQGGKLVCRAHNR9GRCGVYAIARCCLLP 501-------------- v domain ------------------------ 550 PCSK9parent (501) QANCSVHdAPPZEAIN GTI-iViSfdQHQ GHVLTGCSSHVEfldG'IKPPIMLR PCSK9mutants (501) QACSViiAPPA lIiGII Cl liGHVLTGCSSHailIlGi KPFliLR 551---------------------------------------------------600 PCSK9parent (551) PINGdNQCVGHREASIHASCCHAPGLECkVKEIIPAVQEidVTPfCIZGW PCSK9mutants (551) PFIPlQCVGHREASIHASCCHAPGLEC(RRR IPAi ElVT/lCfGW 601--------------------------------------------650 PCSK9parent (601) TLTGCSALPGTSHVLGAYAIMDNTCVVR$NDVSTTGSTSEIEAVTAVAICCN PCSK9mutants (601) TLTGCSALPGTSHVLGAYAliDNTCVVRD ER _ V A 651 --------- 680 PCSK9parent (651) SPHLAQASQELQGSSDYKDDDKHHHHHHHH (SEQ ID NO:303) PCSK9mutants (651) S&HLAQASQELQGSSDYKDDDKHHHHHHHH (SEQ ID NO:304)
申请公布号
AU2013203751(B2)
申请公布日期
2016.09.22
申请号
AU20130203751
申请日期
2013.04.11
申请人
Amgen Inc.
发明人
Shan, Bei;Jackson, Simon Mark;Walker, Nigel Pelham Clinton;Piper, Derek Evan;Chan, Joyce Chi Yee;King, Chadwick Terence;Ketchem, Randal Robert;Mehlin, Christopher;Shen, Wenyan;Cao, Qiong
分类号
C07K16/40;A61K39/395;A61P3/06
主分类号
C07K16/40
代理机构
代理人
主权项
地址
您可能感兴趣的专利
SURFACE TREATMENT METHOD FOR ALUMINUM MATERIAL AND SURFACE TREATED ALUMINUM MATERIAL
CLEANING TREATMENT EQUIPMENT FOR METALLIC WEB
HIGH PURITY Co-Fe ALLOY SPUTTERING TARGET, MAGNETIC THIN FILM DEPOSITED BY USING SAME SPUTTERING TARGET AND METHOD FOR PRODUCING SAME HIGH PURITY Co-Fe ALLOY SPUTTERING TARGET
ALUMINUM ALLOY WIRE FOR MIG WELDING
DIRECTLY ENERGIZED HARDENING APPARATUS FOR THIN WORK
METHOD FOR MANUFACTURING SINTERED BODY, AND SINTERED BODY
AQUEOUS DISPERSION AS WATER/OIL REPELLENT AND METHOD FOR PRODUCING THE SAME
HEAT-RESISTANT ADHESIVE
PRODUCING FACILITY USED FOR BOTH OF COLD-ROLLED STEEL SHEET AND HOT-DIP COATED STEEL SHEET
USAGE OF DOUBLE-SIDED SELF-ADHESIVE TAPE, AND DOUBLE-SIDED SELF-ADHESIVE TAPE AND MANUFACTURING METHOD THEREFOR
STAIN-PREVENTIVE/DEFOGGING COATING AGENT, STAIN-PROOF/ DEFOGGING COATED PRODUCT, AND STAIN-PROOF/DEFOGGING CONSTRUCTION MATERIAL
AQUEOUS RESIN COMPOSITION, PRODUCTION METHOD FOR AQUEOUS RESIN COMPOSITION, AQUEOUS COATING MATERIAL, METHOD FOR FORMING COATING FILM, AND COATED ARTICLE
METHOD FOR AFTERTREATMENT IN PRODUCTION OF ALKOXY- CONTAINING SILICONE COMPOUNDS AND METHOD FOR PRODUCING THE COMPOUNDS
RESIN COMPOSITION FOR HEAT SINK FORMATION AND SEALED ELECTRONIC PART DEVICE
THERMOSETTING POWDER COATING COMPOSITION
METHOD FOR PRODUCING 1,3-DIMETHYL-2-IMIDAZOLIDINONE
MITICIDE FOR ERIOPHYIDAE
AQUEOUS WATER ABSORPTION PREVENTIVE MATERIAL
HAIR COSMETIC
METHOD OF MANUFACTURING GLASS FORMING, METHOD OF MANUFACTURING PREFORM FOR PRESS FORMING, METHOD OF MANUFACTURING PRESS FORMED GOODS AND METHOD OF MANUFACTURING OPTICAL ELEMENT