发明名称 |
UNIVERSAL ANTIBODY-MEDIATED BIOSENSOR |
摘要 |
A universal antibody-mediated biosensor is provided that comprise a biosensor cell line stably expressing a novel chimeric fusion protein that can be used to detect target agents in a sample. The fusion protein has an extracellular antibody-binding domain that binds antibodies without regard to their binding specificity and a signaling domain that induces cellular activation upon antigen binding. Because the fusion protein binds to the Fc region of any antibody, it can serve as a universal pathway between extracellular signaling and intracellular activation. The biosensor can be used to detect the presence of selected antigens in a sample. |
申请公布号 |
WO2016149109(A1) |
申请公布日期 |
2016.09.22 |
申请号 |
WO2016US22060 |
申请日期 |
2016.03.11 |
申请人 |
SCHULZE, Dan;UNIVERSITY OF MARYLAND, BALTIMORE |
发明人 |
SCHULZE, Dan |
分类号 |
C07K19/00;C12Q1/02;G01N33/53 |
主分类号 |
C07K19/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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