| 发明名称 |
METHOD FOR PRODUCING ANTIBODIES HAVING IMPROVED PROPERTIES |
| 摘要 |
PROBLEM TO BE SOLVED: To provide methods and compositions for production of glycosylated proteins (glycoproteins), particularly, Fc-containing polypeptides having improved properties which are useful as human or animal therapeutic agents.SOLUTION: The methods include mutations at positions 243 and 264 of an Fc region in an Fc-containing polypeptide, and glycoengineering with yeast strain Pichia pastoris which mimics a process of glycosylation in humans.SELECTED DRAWING: Figure 1 |
| 申请公布号 |
JP2016155838(A) |
申请公布日期 |
2016.09.01 |
| 申请号 |
JP20160054741 |
申请日期 |
2016.03.18 |
| 申请人 |
MERCK SHARP & DOHME CORP |
发明人 |
TERRANCE A STADHEIM;ZHA DONGXING;LIU LIMING |
| 分类号 |
C07K16/00;A61K38/00;A61K39/395;A61K48/00;A61P1/04;A61P1/14;A61P3/10;A61P7/00;A61P7/02;A61P7/04;A61P7/06;A61P9/00;A61P9/04;A61P9/10;A61P9/12;A61P11/06;A61P13/08;A61P13/10;A61P13/12;A61P17/00;A61P17/06;A61P17/10;A61P19/02;A61P21/00;A61P21/02;A61P25/00;A61P25/02;A61P25/28;A61P29/00;A61P31/04;A61P31/18;A61P35/00;A61P35/02;A61P37/02;A61P37/06;A61P37/08;A61P43/00;C12P21/08 |
主分类号 |
C07K16/00 |
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