VARIANT ACTIVIN RECEPTOR POLYPEPTIDES AND USES THEREOF
摘要
The present invention provides variant activin IIB soluble receptor polypeptides and proteins capable of binding and inhibiting the activities of activin A, myostatin, or GDF-11. The present invention also provides polynucleotides, vectors and host cells capable of producing the variant polypeptides and proteins. Compositions and methods for treating muscle-wasting and other diseases and disorders are also provided.
申请公布号
WO2008109167(A3)
申请公布日期
2009.06.18
申请号
WO2008US03119
申请日期
2008.03.06
申请人
AMGEN INC.;SUN, JEONGHOON;TAM, LEI-TING TONY;HAN, HQ;KWAK, KEITH SOO-NYUNG;ZHOU, XIAOLAN
发明人
SUN, JEONGHOON;TAM, LEI-TING TONY;HAN, HQ;KWAK, KEITH SOO-NYUNG;ZHOU, XIAOLAN