| 摘要 |
PROBLEM TO BE SOLVED: To provide a method and system for processing and removal of one or more target compounds from CSF of a patient.SOLUTION: The present invention provides methods and systems for conditioning cerebrospinal fluid (CSF). The methods provide efficient removal of target compounds from CSF. The systems provide a multilumen flow path and exchange of a majority volume portion of CSF in the CSF space. The removal and/or delivery of specific compounds can be tailored to the pathology of the specific disease. The removal is targeted and specific, for example, through the use of specific size-exclusion thresholds, antibodies against specific toxins, and other chromatographic techniques, as well as delivery and/or removal of targeted therapeutic agents. The invention finds use as a diagnostic, therapeutic and drug delivery platform for a variety of diseases affecting the CNS by accessing the CSF space.SELECTED DRAWING: Figure 8-1 |
