| 发明名称 |
ALKENE PRODUCTION |
| 摘要 |
The present invention provides a microbial cell capable of producing at least one terminal alkene from at least one short chain fatty acid, wherein the cell is genetically modified to comprise
at least a first genetic mutation that increases the expression relative to the wild type cell of an enzyme (E1) selected from the CYP152 peroxygenase family, andat least a second genetic mutation that increases the expression relative to the wild type cell of at least one NAD(P)+ oxidoreductase (E2) and the corresponding mediator protein,wherein the short chain fatty acid is a C4-C10 fatty acid. |
| 申请公布号 |
US2016326549(A1) |
申请公布日期 |
2016.11.10 |
| 申请号 |
US201615053626 |
申请日期 |
2016.02.25 |
| 申请人 |
DENNIG Alexander;FABER Kurt;Hall Melanie;Haas Thomas;Buelter Thomas;Gilch Stefan;Thiessenhusen Anja |
发明人 |
DENNIG Alexander;FABER Kurt;Hall Melanie;Haas Thomas;Buelter Thomas;Gilch Stefan;Thiessenhusen Anja |
| 分类号 |
C12P5/00;C12N9/08;C12N9/02 |
主分类号 |
C12P5/00 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A microbial cell capable of producing at least one terminal alkene from at least one short chain fatty acid, wherein the cell is genetically modified to comprise
at least a first genetic mutation that increases the expression relative to the wild type cell of an enzyme (E1) selected from the CYP152 peroxygenase family, and at least a second genetic mutation that increases the expression relative to the wild type cell of at least one NAD(P)+ oxidoreductase (E2) and the corresponding mediator protein, wherein the short chain fatty acid is a C4-C10 fatty acid. |
| 地址 |
Graz AT |
