METHOD FOR PRODUCING KAKEROMYCIN AND DERIVATIVES THEREOF

摘要

Provided is a method for producing, through chemical synthesis, kakeromycin and derivatives thereof which exhibit antifungal activity and cytotoxicity, and are expected to serve as novel antifungal agents or anticancer agents. Said method includes a step in which a compound represented by formula (2) [wherein, R represents an optionally substituted hydrocarbon group or an optionally substituted heterocyclic group, and n represents 0 or 1] or a salt thereof is subjected to an oxidation reaction, and a compound represented by formula (1) [wherein, R and n are as defined above] or a salt thereof is produced.