发明名称 |
PROCESS FOR PREPARATION OF CINACALCET INTERMEDIATE AND CINACALCET HYDROCHLORIDE |
摘要 |
The present invention provides one pot process for preparation of highly pure unsaturated cinacalcet hydrochloride (II) comprising: i) converting 3-(trifluromethyl) cinnamic acid (III) into 3-(3-(trifluoromethyl)phenyl)prop-2-en-1-ol (IV), ii) converting 3-(3-(trifluoromethyl)phenyl)prop-2-en-1-ol (IV) to compound (V), wherein R is Cl, Br, I, tosylate and mesylate, Formula (V) iii) reacting compound (V) with (R)-1-(1-Naphthyl) ethylamine (VI) in presence of base followed by treatment with hydrochloric acid. The present invention further provides conversion of unsaturated cinacalcet hydrochloride (II) to cinacalcet hydrochloride (I). |
申请公布号 |
WO2016193882(A1) |
申请公布日期 |
2016.12.08 |
申请号 |
WO2016IB53127 |
申请日期 |
2016.05.27 |
申请人 |
LUPIN LIMITED |
发明人 |
GAIKWAD, Vishal, Gautam;PATIL, Sadanand, Nilkanth;SIYAN, Rajinder, Singh;BHISE, Nandu, Baban;SINGH, Girij, Pal |
分类号 |
C07C17/16;C07C22/08;C07C29/147;C07C31/38;C07C209/08;C07C209/70;C07C211/30 |
主分类号 |
C07C17/16 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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