| 摘要 |
PROBLEM TO BE SOLVED: To provide methods for rapidly inducing a protective immune response in an animal including human, comprising the step of administering to the animal including human a pox virus not capable of replicating in the animal including human.SOLUTION: The present invention relates to a rapid induction of a protective immune response against a poxvirus and poxvirus infection such as smallpox by vaccinating an animal including human with a replication deficit poxvirus in the animal. An example of such a poxvirus is a Modified Vaccinia virus Ankara (MVA). The invention further relates to a method of the use of a recombinant poxvirus which is replication deficit in an animal including human to be vaccinated with the virus, such as a recombinant MVA expressing a heterologous antigen and/or antigenic epitope for a rapid induction of a protective immune response e.g., against the antigen and/or antigenic epitope being a part of an infectious agent.SELECTED DRAWING: None |
