| 发明名称 |
RNAi Inhibition of Alpha-ENaC Expression |
| 摘要 |
The invention relates to compositions and methods for modulating the expression of alpha-ENaC, and more particularly to the downregulation of alpha-ENaC expression by chemically modified oligonucleotides. |
| 申请公布号 |
US2016376599(A1) |
申请公布日期 |
2016.12.29 |
| 申请号 |
US201615260824 |
申请日期 |
2016.09.09 |
| 申请人 |
Arrowhead Pharmaceuticals, Inc. |
发明人 |
Van Heeke Gino;Hickman Emma;Danahay Henry Luke;Tan Pamela;Geick Anke;Vornlocher Hans-Peter |
| 分类号 |
C12N15/113;A61K31/713;A61K45/06 |
主分类号 |
C12N15/113 |
| 代理机构 |
|
代理人 |
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| 主权项 |
1. A composition comprising an iRNA agent comprising a sense strand and an antisense strand, wherein: the antisense strand comprises a nucleotide sequence of nucleotides 2-18 of SEQ ID NO:400, SEQ ID NO:506, SEQ ID NO:686, or SEQ ID NO: 1120. |
| 地址 |
Pasadena CA US |
