发明名称 CYCLIC COMPOUNDS AND USES THEREOF
摘要 The invention generally relates to substituted benzothiophenyl, substituted benzothiazolyl, substituted indolyl and substituted benzoimidazolyl compounds and, more particularly, to a compound represented by Structural Formula I: or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula I, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of a disease or disorder selected from cancer (e.g., lymphoma, such as mantle cell lymphoma), a neurodegenerative disease, inflammatory diseases or an autoimmune system disease (e.g., a T-Cell mediated autoimmune disesase).
申请公布号 WO2016100515(A1) 申请公布日期 2016.06.23
申请号 WO2015US66098 申请日期 2015.12.16
申请人 KARYOPHARM THERAPEUTICS INC. 发明人 BALOGLU, ERKAN;SENAPEDIS, WILLIAM;SHACHAM, SHARON
分类号 C07D401/14;A61K31/4436;A61K31/4439;A61K31/444;A61K31/4545;A61K31/5377;A61P25/00;A61P29/00;A61P35/00;A61P37/00;C07D409/12;C07D409/14;C07D417/14;C07D491/107 主分类号 C07D401/14
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