CASPASE 1 TRANSGENES TIER

摘要

A transgenic non-human mammal or its offspring which carries DNA having exogenous caspase 1 gene integrated thereinto in such a manner as to express the gene specifically to skin. In view that the transgenic non-human mammal of the present invention spontaneously develops atopic dermatitis in the absence of any specific pathogenic microorganism, the mammal is useful as a disease model animal. Use of the transgenic animal of the present invention enables development of preventive and/or therapeutic drugs for atopic dermatitis based on natural immunity and to clarify the onset mechanism of atopic diseases.